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pentobarbital decreases levels of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. stay away from coadministration with potent CYP3A4 inducers; these drugs cut down publicity to vandetanib by as many as forty%. Pentobarbital is actually a barbiturate drug used to induce slumber, induce sedation, and control par